The collaborating research teams found that a high-fat diet causes inflammation and damages intestinal epithelial cells in animal models. The high-fat diet impairs the function of energy-generating mitochondria, Byndloss explained, causing the intestinal cells to produce more oxygen and nitrate.
These factors, in turn, stimulate the growth of harmful Enterobacteriaceae microbes, such as E. coli, and boost bacterial production of a metabolite called TMA (trimethylamine). The liver converts TMA to TMAO (trimethylamine-N-oxide), which has been implicated in promoting atherosclerosis and increasing the relative risk for all-cause mortality in patients.
Vanderbilt University Medical Center. “Study reveals missing link between high-fat diet, microbiota and heart disease.” ScienceDaily. http://www.sciencedaily.com/releases/2021/08/210812145052.htm (accessed August 14, 2021).
OK so maybe I’ve exaggerated a wee bit about most of us having knowledge about TMAO (trimethylamine-N-oxide). If the news about TMAO is new to you I suggest visiting Dr. Michael Greger’s website www.nutritionfacts.org and start here: https://nutritionfacts.org/2020/09/29/updating-our-microbiome-software-and-hardware/
garyskitchen.net 
New to me!